Imcivree (Setmelanotide) Vial

Imcivree is an injectable medication used for weight management in people with certain genetic conditions. It’s convenient because it only needs to be injected once a day, but it can cause serious side effects like depression, suicidal thoughts, and problems with sexual function.

Imcivree is the first treatment for obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency. Imcivree has helped people 6 years of age and older lose weight and keep it off.

Imcivree should not be used for obesity due to suspected POMC, PCSK1, or LEPR deficiency not confirmed by genetic testing (benign or likely benign result), nor other types of obesity, including those associated with other genetic syndromes and general obesity.

Uses Of Imcivree Vial

• It is used for weight control in patients with proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency.

Benefits Of Imcivree Vial

Chronic (long-term) weight management in people aged 6 years and older with obesity due to certain genetic conditions (e.g., proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency)

Side Effects Of Imcivree Vial

• Depression, suicidal thoughts and behavior
• Problems with sexual function: erections lasting longer than 4 hours
• Gasping syndrome (in newborns and infants): gasping breaths, buildup of acid in the blood, slowing of brain function, kidney failure, seizures

Common Side Effects Of Imcivree Vial

• Injection site discomfort (e.g., redness, itchiness, swelling, pain, bruising) (96%)
• Darkening or discoloration of the skin (78%)
• Nausea (56%)
• Headache (41%)
• Diarrhea (37%)
• Stomach pain (33%)
• Back pain (33%)
• Tiredness (30%)
• Vomiting (30%)
• Depression (26%)
• Upper respiratory infection (26%)
• Unplanned penile erections (23%)
• Joint pain (19%)
• Weakness or lack of energy (19%)

How To Use Imcivree Vial

Imcivree is a prescription medicine used in adults and children 6 years of age and older with obesity due to the genetic conditions proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency, to help them lose weight and keep the weight off.

Your healthcare provider should order a genetic test to confirm POMC, PCSK1, or LEPR deficiency before you start using Imcivree.

Imcivree is not for use in people with the following conditions because it may not work:
Obesity due to suspected POMC, PCSK1, or LEPR deficiency not confirmed by genetic testing (benign or likely benign result).

Other types of obesity not related to POMC, PCSK1, or LEPR deficiency, including obesity associated with other genetic conditions and general obesity.

How Imcivree Vial Works

Imcivree Vial is a melanocortin agonist. It binds to melanocortin receptors in your brain to lower your appetite and make your body use up more energy. This helps promote weight loss.